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In the greater Tampa Bay region, there were nearly 40,000 new cases. The state also reported 1,727 deaths this week.
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The deaths, which may have occurred over the past several days or weeks, bring the state's coronavirus overall death toll to 43,632.
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The number of people in Florida's hospitals with the coronavirus rose by 76 on Wednesday, bringing the total to 17,164.
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While the deaths were recorded on Saturday and Sunday, they may have occurred in previous weeks or months.
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For the week ending on Thursday, the state reported an additional 150,118 cases of the coronavirus — the second highest weekly total, trailing only last week.
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Polk County Fire Rescue is responding to close to 400 calls a day in Polk County, nearly 100 above the average.
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The seven-day rolling average for new cases climbed to 21,375.
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NPR's Debbie Elliott talks to Orlando-based epidemiologist Dr. Vincent Hsu about the state's strained health care resources amid a new surge of coronavirus cases. He says it's the worse it's ever been.
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Those who end up in a hospital for COVID-19 are more than twice as likely to be hospitalized in the future for additional health problems related to a COVID-19 complication, researchers found.
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About 50 ambulances a day are having to wait over an hour to offload patients because emergency rooms do not have the space or staff for new patients, officials said.
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The health department, which no longer publishes daily numbers, tweeted that Friday's daily case count was actually 21,500, Saturday's was 19,567 and Sunday's was 15,319.
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The temporary stay keeps in place the CDC regulations regarding Florida-based cruise ships in place, while the agency appeals a Tampa federal judge's June decision.