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Health officials in Hillsborough County are urging people to make appointments and to prepare to spend about half a day at the site.
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Patients at high-risk of developing severe COVID-19 — including those with obesity or lung disease — can get the treatment, which DeSantis has been touting.
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Gov. Ron DeSantis, who promised that additional sites would open in the coming days, said he wanted to promote the availability of the treatment and to expand access to it.
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The state will open clinics to distribute the treatments to relieve pressure on hospital emergency rooms amid the latest surge.
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The treatment is proving to be an effective tool at preventing severe illness, but patients who test positive for COVID-19 have to get it early in order for it to work well.